A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response (Q24299489)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GOA release 2020-03-11

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GOA release 2020-03-11

author

Stephen Elledge

4

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author name string

Dong Zhang

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Kathrin Zaugg

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Tak W Mak

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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language of work or name

English

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publication date

11 August 2006

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published in

Cell

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volume

126

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issue

3

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page(s)

529-42

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cites work

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

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Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.

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p53 linear diffusion along DNA requires its C terminus

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The Hallmarks of Cancer

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Cell death: critical control points

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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A generic protein purification method for protein complex characterization and proteome exploration

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Surfing the p53 network

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The DNA damage response: putting checkpoints in perspective

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Mrc1 transduces signals of DNA replication stress to activate Rad53.

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Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

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p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53

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Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

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Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

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53BP1 is required for class switch recombination

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The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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Degrading Ci: who is Cul-pable?

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

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ATR and ATRIP: partners in checkpoint signaling

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53BP1, a mediator of the DNA damage checkpoint

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25

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