Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway (Q24299670)

Hypoxia inducible factor 1 subunit alpha

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E1A binding protein p300

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Endothelial PAS domain protein 1

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histone acetyltransferase binding

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E1A binding protein p300

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Andrew L Kung

1

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author name string

Sonya D Zabludoff

2

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Dennis S France

3

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Steven J Freedman

4

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Elizabeth A Tanner

5

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Annelisa Vieira

6

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Susan Cornell-Kennon

7

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Jennifer Lee

8

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Beqing Wang

9

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Jamin Wang

10

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Klaus Memmert

11

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Hans-Ulrich Naegeli

12

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Frank Petersen

13

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Michael J Eck

14

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Kenneth W Bair

15

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Alexander W Wood

16

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David M Livingston

17

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language of work or name

English

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publication date

July 2004

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number of pages

11

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Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

inferred from page(s)

published in

Cancer Cell

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volume

6

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issue

1

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page(s)

33-43

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2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

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Regulation of angiogenesis by hypoxia: role of the HIF system

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Hypoxia--a key regulatory factor in tumour growth

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Transcription factors as targets for cancer therapy

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Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2

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Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

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An essential role for p300/CBP in the cellular response to hypoxia

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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Small molecule modulators of histone acetyltransferase p300.

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Hypoxia-inducible factor and its biomedical relevance

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

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Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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