A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein (Q24299850)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17986458%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein (English)

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9 January 2020

4

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9 January 2020

author name string

Claudia Bex

series ordinal

1

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9 January 2020

Katja Knauth

series ordinal

2

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9 January 2020

Silvia Dambacher

series ordinal

3

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9 January 2020

language of work or name

English

0 references

publication date

5 November 2007

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9 January 2020

published in

Nucleic Acids Research

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9 January 2020

volume

35

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9 January 2020

issue

21

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9 January 2020

page(s)

e142

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ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

9 January 2020

cites work

1 reference

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

19 March 2017

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

19 March 2017

1 reference

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The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity

19 March 2017

1 reference

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Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

19 March 2017

1 reference

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

19 March 2017

1 reference

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

19 March 2017

1 reference

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Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

19 March 2017

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

19 March 2017

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

19 March 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

19 March 2017

1 reference

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Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The cloning and characterization of a novel human diacylglycerol kinase, DGKiota

19 March 2017

1 reference

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Targeting HIF-1 for cancer therapy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Function and regulation of cullin-RING ubiquitin ligases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

von Hippel-Lindau disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The SOCS box: a tale of destruction and degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Regulation of angiogenesis by hypoxia: role of the HIF system

7 April 2017

1 reference

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Identification of protein interaction antagonists using the repressed transactivator two-hybrid system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

pVHL and GSK3beta are components of a primary cilium-maintenance signalling network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

27 September 2017

1 reference

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The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

27 September 2017

1 reference

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Signaling roles of diacylglycerol kinases

27 September 2017

1 reference

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The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.

27 September 2017

1 reference

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The SH2 domain: versatile signaling module and pharmaceutical target

27 September 2017

1 reference

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Role of VHL gene mutation in human cancer

27 September 2017

1 reference

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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The HIF pathway as a therapeutic target

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

HIF-1 as a target for drug development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

High-throughput screening for protein-protein interactions using two-hybrid assay

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Analyzing protein-protein interactions using two-hybrid system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.

27 September 2017

1 reference

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The von Hippel-Lindau tumor suppressor protein is a molten globule under native conditions: implications for its physiological activities

29 November 2018

1 reference

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Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2175351

von Hippel-Lindau disease

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17986458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17986458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The VHL tumour-suppressor gene paradigm

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17986458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKM932

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17986458%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17986458%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17986458

2 references