Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505 (Q24299998)

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27 December 2019

title

Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505 (English)

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27 December 2019

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GOA release 2020-03-11

DNA topoisomerase type I (single strand cut, ATP-independent) activity

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GOA release 2020-03-11

author

Laurent Rivory

3

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27 December 2019

Jacques Robert

4

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27 December 2019

author name string

Danièle Montaudon

1

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27 December 2019

Komaraiah Palle

2

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27 December 2019

Céline Douat-Casassus

5

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27 December 2019

Stéphane Quideau

6

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27 December 2019

Mary-Ann Bjornsti

7

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27 December 2019

Philippe Pourquier

8

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27 December 2019

language of work or name

English

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publication date

12 March 2007

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Journal of Biological Chemistry

27 December 2019

published in

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27 December 2019

volume

282

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27 December 2019

issue

19

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27 December 2019

page(s)

14403-14412

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Cellular roles of dna topoisomerases: a molecular perspective

27 December 2019

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Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB.

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Effect of minor groove binding drugs on mammalian topoisomerase I activity

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DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin

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Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation

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Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells.

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

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DNA topoisomerases: structure, function, and mechanism

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Eukaryotic DNA topoisomerases I.

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Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

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Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

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Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

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Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress

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Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

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A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

21 January 2018

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New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site

21 January 2018

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Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases

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The 11 beta-hydroxysteroid dehydrogenase type 2 activity in human placental microsomes is inactivated by zinc and the sulfhydryl modifying reagent N-ethylmaleimide

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Mechanistic studies on CDP-6-deoxy-delta 3,4-glucoseen reductase: the role of cysteine residues in catalysis as probed by chemical modification and site-directed mutagenesis

21 January 2018

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Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

21 January 2018

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

21 January 2018

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Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA

21 January 2018

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Biochemical and biophysical analyses of recombinant forms of human topoisomerase I

21 January 2018

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Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

21 January 2018

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8-Oxoguanine rearranges the active site of human topoisomerase I

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Identification and characterization of the N-ethylmaleimide-sensitive site in lambda-integrase

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Identifiers

DOI

10.1074/JBC.M611673200

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27 December 2019

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