RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins (Q24300411)

positive regulation of DNA repair

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

5

Jiri Bartek

0 references

Jiří Lukáš

7

object named as

Jiri Lukas

0 references

Claudia Lukas

object named as

Claudia Lukas

6

0 references

Simon Bekker-Jensen

object named as

Simon Bekker-Jensen

Helene Faustrup Kildegaard

2

0 references

1 reference

ORCID Public Data File 2021

author name string

Niels Mailand

1

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Helene Faustrup

3

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Fredrik Melander

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

4

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language of work or name

English

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publication date

30 November 2007

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published in

Cell

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volume

131

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issue

5

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page(s)

887-900

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Chromatin modifications and their function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

H2AX: the histone guardian of the genome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Role of histone H2A ubiquitination in Polycomb silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Cellular functions of the BRCA tumour-suppressor proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Direct DNA binding by Brca1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.09.040

7 January 2021