IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling (Q24300924)

GOA release 2020-03-11

author name string

Grigory Ryzhakov

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Katrina Blazek

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Cheryl Chuk-ke Lai

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Irina A Udalova

The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody

4

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language of work or name

English

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publication date

15 November 2012

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published in

Journal of Immunology

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volume

189

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issue

10

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page(s)

4852-8

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cites work

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CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy

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Role of the adaptor protein CIKS in the activation of the IKK complex

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NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

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The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

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The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

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Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene

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Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells

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Act1, an NF-kappa B-activating protein

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CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

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Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor

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Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3

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Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases

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Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation

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Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

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Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

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Innate cellular response to virus particle entry requires IRF3 but not virus replication

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IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6

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