Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells (Q24301060)

negative regulation of transforming growth factor beta receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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1 reference

Jun-ichirou Yasunaga

3

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Masao Matsuoka

object named as

Masao Matsuoka

6

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author name string

Mika Yoshida

1

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Kisato Nosaka

2

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Ichiro Nishikata

4

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Kazuhiro Morishita

Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia

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language of work or name

English

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publication date

1 April 2004

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published in

Blood

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volume

103

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issue

7

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page(s)

2753-60

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cites work

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Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1.

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Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on non-Hodgkin lymphoma incidence in southwestern Japan.

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

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Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

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A novel sperm-specific hypomethylation sequence is a demethylation hotspot in human hepatocellular carcinomas.

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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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Hypomethylation distinguishes genes of some human cancers from their normal counterparts

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Human T-lymphotropic retroviruses

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

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DNA methylation in cancer: too much, but also too little

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Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis

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Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

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Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

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Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

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The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

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Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family

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Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors

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The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression.

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SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes

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Isolation of NotI clusters hypomethylated in HBV-integrated hepatocellular carcinomas by two-dimensional electrophoresis.

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The 5-methylcytosine content of DNA from human tumors

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Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily

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The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms

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Induction of Tumors in Mice by Genomic Hypomethylation

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Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family

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Hypomethylation of DNA from benign and malignant human colon neoplasms

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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

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Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family

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Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis.

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A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation

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Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

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Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappa B ligand on adult T-cell leukemia cells

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