STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation (Q24301291)

signal transducer and activator of transcription 3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Matthias W Hentze

5

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Martina U Muckenthaler

6

object named as

Martina U Muckenthaler

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author name string

Maria Vittoria Verga Falzacappa

1

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Maja Vujic Spasic

2

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Regina Kessler

3

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Jens Stolte

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

4

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language of work or name

English

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publication date

1 January 2007

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published in

Blood

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volume

109

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issue

1

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page(s)

353-8

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cites work

1 reference

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Balancing acts: molecular control of mammalian iron metabolism

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Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

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Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

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Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

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7 January 2021

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.

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7 January 2021

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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IL-6-induced anaemia in rats: possible pathogenetic implications for anemia observed in chronic inflammations

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Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)

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7 January 2021

The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes

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Regulation of hepcidin transcription by interleukin-1 and interleukin-6.

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

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7 January 2021

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

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MatInspector and beyond: promoter analysis based on transcription factor binding sites

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TGF‐β down‐regulates IL‐6 signaling in intestinal epithelial cells: Critical role of SMAD‐2

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7 January 2021

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

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First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

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Iron imports. IV. Hepcidin and regulation of body iron metabolism

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Interleukin 1 administration in mice produces hypoferremia despite neutropenia

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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7 January 2021

A mouse model of juvenile hemochromatosis

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7 January 2021

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

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7 January 2021

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

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7 January 2021

Hepcidin is decreased in TFR2 hemochromatosis

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7 January 2021

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

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7 January 2021

Hereditary hemochromatosis: genetic complexity and new diagnostic approaches

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