Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart (Q24301492)

nucleic acid phosphodiester bond hydrolysis

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

R Hromas

1

0 references

E A Williamson

2

0 references

S Fnu

3

0 references

Y-J Lee

4

0 references

S-J Park

5

0 references

B D Beck

6

0 references

J-S You

7

0 references

A Leitao

8

0 references

A Laitao

9

0 references

J A Nickoloff

10

0 references

S-H Lee

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

11

0 references

language of work or name

English

0 references

publication date

20 September 2012

0 references

published in

Oncogene

0 references

volume

31

0 references

issue

38

0 references

page(s)

4245-54

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

19 March 2017

The Protein Model Portal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Birth of a chimeric primate gene by capture of the transposase gene from a mobile element

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Use of chromatin immunoprecipitation to clone novel E2F target promoters

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Initial sequencing and analysis of the human genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Regulation and mechanisms of mammalian double-strand break repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Interaction of FANCD2 and NBS1 in the DNA damage response

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Substrate specificities and identification of putative substrates of ATM kinase family members

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA-damaging agents. Similarities and differences to alpha-PAK

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Protein kinase C isoforms: Multi-functional regulators of cell life and death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Metnase promotes restart and repair of stalled and collapsed replication forks

19 March 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

Regulating mammalian checkpoints through Cdc25 inactivation

22 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity

22 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

22 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations

22 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

The DNA damage response: putting checkpoints in perspective

22 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2011.586

Evolutionary tinkering with transposable elements

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Replication protein A (RPA) phosphorylation prevents RPA association with replication centers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Repair of DNA double strand breaks by non-homologous end joining

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

DNA damage-dependent nuclear dynamics of the Mre11 complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Integrating DNA: transposases and retroviral integrases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Dynamics of human replication protein A subunit distribution and partitioning in the cell cycle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Nuclear localization signals (NLS).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Chk1 and Chk2 kinases in checkpoint control and cancer

27 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

An in vivo analysis of MMC-induced DNA damage and its repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

p21-activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-damaging Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

Metnase mediates chromosome decatenation in acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

A positive involvement of RecQL4 in UV-induced S-phase arrest.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

An Arabidopsis hAT-like transposase is essential for plant development.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

A Positive Role for the Ku Complex in DNA Replication Following Strand Break Damage in Mammals

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

Chk2 leaves the PML depot

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963179

29 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.586

Cyclic Nucleotide-independent protein kinases from rabbit reticulocytes. Identification and characterization of a protein kinase activated by proteolysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22231448

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of phosphorylation of avian retrovirus nucleocapsid protein pp12 on binding of viral RNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22231448