Metnase promotes restart and repair of stalled and collapsed replication forks (Q24311504)

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

7

Neil Osheroff

0 references

author name string

Leyma P De Haro

1

0 references

Justin Wray

2

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Elizabeth A Williamson

3

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Stephen T Durant

4

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Lori Corwin

5

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Amanda C Gentry

6

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Suk-Hee Lee

8

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Robert Hromas

9

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Jac A Nickoloff

Creative Commons Attribution-NonCommercial 2.5 Generic

10

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language of work or name

English

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publication date

September 2010

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published in

Nucleic Acids Research

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volume

38

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page(s)

5681-91

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issue

17

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copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2943610/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells

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The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

19 March 2017

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Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair

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The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

19 March 2017

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

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Rad52 forms DNA repair and recombination centers during S phase

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

19 March 2017

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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

19 March 2017

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Metnase mediates chromosome decatenation in acute leukemia cells

27 September 2017

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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

27 September 2017

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Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress

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Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

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The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining

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