Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha (Q24301526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889502%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha (English)

1 reference

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14 February 2020

0 references

0 references

Hypoxia inducible factor 1 subunit alpha

1 reference

GOA release 2020-03-11

Polo like kinase 3

1 reference

positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889502%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Yixin Yao

2

1 reference

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14 February 2020

Wei Dai

5

1 reference

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14 February 2020

author name string

Luo Lu

3

1 reference

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14 February 2020

Max Costa

4

1 reference

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14 February 2020

language of work or name

English

0 references

publication date

1 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889502%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

14 February 2020

published in

1 reference

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14 February 2020

volume

285

1 reference

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14 February 2020

issue

50

1 reference

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14 February 2020

page(s)

38944-38950

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A complex interplay between Akt, TSC2 and the two mTOR complexes

14 February 2020

cites work

1 reference

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Polo-like kinase 3 is required for entry into S phase

19 March 2017

1 reference

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Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity

19 March 2017

1 reference

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Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

19 March 2017

1 reference

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The physical association and phosphorylation of Cdc25C protein phosphatase by Prk

19 March 2017

1 reference

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Polo-like kinases and the orchestration of cell division

19 March 2017

1 reference

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

7 April 2017

1 reference

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7 April 2017

1 reference

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Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypox

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Polo-like kinases, an introduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

27 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Targeting polo-like kinase 1 for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160325

Molecular analysis of 1p32 genetic involvement in pediatric T-cell non-Hodgkin's lymphoma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998109

Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20889502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia-Inducible Factor-1 (HIF-1)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20889502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.160325

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889502%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889502%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

20889502

1 reference