A complex interplay between Akt, TSC2 and the two mTOR complexes (Q24655791)

Biochemical Society Transactions

Europe PubMed Central

title

A complex interplay between Akt, TSC2 and the two mTOR complexes (English)

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author name string

Jingxiang Huang

series ordinal

1

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Brendan D Manning

series ordinal

2

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language of work or name

English

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publication date

February 2009

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published in

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volume

37

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page(s)

217-22

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issue

Pt 1

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cites work

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

7 April 2017

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

7 April 2017

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AKT/PKB signaling: navigating downstream

7 April 2017

1 reference

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

7 April 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 April 2017

1 reference

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

7 April 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

7 April 2017

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

7 April 2017

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

7 April 2017

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

7 April 2017

1 reference

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

7 April 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

7 April 2017

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TOR signaling in growth and metabolism

7 April 2017

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

7 April 2017

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Upstream and downstream of mTOR

7 April 2017

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

7 April 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 April 2017

1 reference

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

7 April 2017

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

7 April 2017

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

7 April 2017

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 April 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

7 April 2017

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The tuberous sclerosis complex

7 April 2017

1 reference

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

7 April 2017

1 reference

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Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

1 reference

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

7 April 2017

1 reference

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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

28 September 2017

1 reference

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FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

28 September 2017

1 reference

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Restraining PI3K: mTOR signalling goes back to the membrane.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026

Rheb fills a GAP between TSC and TOR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026

The many forks in FOXO's road

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026

28 November 2018

Identifiers

DOI

10.1042/BST0370217

1 reference

release_6v2qvw3v65h7vjk5wdoq2geh3y

1398037

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6v2qvw3v65h7vjk5wdoq2geh3y

mapped directly with Wikidata item

24 November 2022

based on heuristic

1398037

1 reference

1 reference

1 reference