Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin (Q24301667)

GOA release 2020-03-11

TOR signaling

1 reference

GOA release 2020-03-11

author name string

Goh Ohji

1

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Sujuti Hidayat

2

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Akio Nakashima

3

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Chiharu Tokunaga

4

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Noriko Oshiro

5

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Ken-Ichi Yoshino

6

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Koichi Yokono

7

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Ushio Kikkawa

8

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Kazuyoshi Yonezawa

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

9

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language of work or name

English

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publication date

January 2006

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published in

Journal of Biochemistry

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volume

139

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issue

1

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page(s)

129-35

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cites work

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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21 January 2018

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

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Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

21 January 2018

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Hsp90: chaperoning signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

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The Hsp90 chaperone complex as a novel target for cancer therapy

21 January 2018

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

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Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.

21 January 2018

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Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

21 January 2018

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

Mammalian target of rapamycin (mTOR) Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

The TOR pathway: a target for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

inferred from DOI database lookup

7 January 2021

based on heuristic

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008

inferred from DOI database lookup

7 January 2021

based on heuristic

4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVJ008