Hsp90 inhibitors as novel cancer chemotherapeutic agents (Q34583912)

3 August 2017

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title

Hsp90 inhibitors as novel cancer chemotherapeutic agents (English)

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3 August 2017

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1

Len Neckers

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3 August 2017

1 January 2002

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Trends in Molecular Medicine

3 August 2017

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3 August 2017

8

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3 August 2017

S55-61

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3 August 2017

4 Suppl

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High constitutive expression of heat shock protein 90α in human acute leukemia cells

3 August 2017

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Unusual expression and localization of heat-shock proteins in human tumor cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Binding of benzoquinoid ansamycins to p100 correlates with their ability to deplete the erbB2 gene product p185

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The Hsp90 complex--a super-chaperone machine as a novel drug target.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

Hsp90 as a capacitor for morphological evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

10.1016/S1471-4914(02)02316-X

Identifiers

DOI

1 reference

release_romesjqirzf3dbxwqr7kvbfrje

3 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/romesjqirzf3dbxwqr7kvbfrje

24 November 2022

mapped directly with Wikidata item

PubMed ID

11927289

1 reference

PubMed ID

11927289