Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers (Q24301676)

GOA release 2020-03-11

author name string

Merel C M Strik

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Angela Wolbink

2

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Dorine Wouters

3

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Bellinda A Bladergroen

4

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Angelique R Verlaan

5

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Inge S van Houdt

6

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Sanne Hijlkema

7

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C Erik Hack

8

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J Alain Kummer

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells

9

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language of work or name

English

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publication date

1 April 2004

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published in

Blood

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volume

103

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issue

7

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page(s)

2710-7

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cites work

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The ovalbumin family of serpin proteins

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Establishment of an immature mast cell line from a patient with mast cell leukemia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The inflammatory response in myocardial infarction

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Mast cells, thrombosis, and fibrinolysis: the emerging concept

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Production, characterization, and use of serpin antibodies

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Inactivation of human lung tryptase: evidence for a re-activatable tetrameric intermediate and active monomers

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Expression, Purification, and Inhibitory Properties of Human Proteinase Inhibitor 8

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Expression, purification, and inhibitory properties of human proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Serpin structure, mechanism, and function

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Formation of active monomers from tetrameric human beta-tryptase

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The Mast Cell in Inflammatory Arthritis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Two types of human mast cells that have distinct neutral protease compositions

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The structure of the human betaII-tryptase tetramer: fo(u)r better or worse

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Molecular Cloning, Expression, and Partial Characterization of Two Novel Members of the Ovalbumin Family of Serine Proteinase Inhibitors

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal trans

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The role of the mast cell in asthma: a reassessment

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Phenotypic characterization of the human mast-cell line HMC-1.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Distribution of the human intracellular serpin protease inhibitor 8 in human tissues

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021

Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-08-2981

7 January 2021