Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal trans (Q34145976)

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English	Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal trans	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal trans (English)

1 reference

Europe PubMed Central

31 July 2017

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transmembrane protein

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author name string

Guang W Wong

1

1 reference

Europe PubMed Central

31 July 2017

Paul S Foster

2

1 reference

Europe PubMed Central

31 July 2017

Shinsuke Yasuda

3

1 reference

Europe PubMed Central

31 July 2017

Jian C Qi

4

1 reference

Europe PubMed Central

31 July 2017

Surendran Mahalingam

5

1 reference

Europe PubMed Central

31 July 2017

Elizabeth A Mellor

6

1 reference

Europe PubMed Central

31 July 2017

Gregory Katsoulotos

7

1 reference

Europe PubMed Central

31 July 2017

Lixin Li

8

1 reference

Europe PubMed Central

31 July 2017

Joshua A Boyce

9

1 reference

Europe PubMed Central

31 July 2017

Steven A Krilis

10

1 reference

Europe PubMed Central

31 July 2017

Richard L Stevens

11

1 reference

Europe PubMed Central

31 July 2017

language of work or name

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publication date

22 August 2002

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Europe PubMed Central

31 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

31 July 2017

277

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Europe PubMed Central

31 July 2017

44

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Europe PubMed Central

31 July 2017

41906-41915

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Europe PubMed Central

31 July 2017

Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Two types of human mast cells that have distinct neutral protease compositions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Cloning and characterization of complementary DNA for human tryptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Cloning and characterization of a second complementary DNA for human tryptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Structural analysis of esp-1 gene (PRSS 21).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Recombinant expression of human mast cell proteases chymase and tryptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Expression and characterization of recombinant mast cell tryptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

A genome-wide search for quantitative trait loci underlying asthma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Mast cell activation enhances airway responsiveness to methacholine in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

IL-12/IL-13 axis in allergic asthma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Activated mast cells produce interleukin 13.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Human lung mast cell activation leads to IL-13 mRNA expression and protein release

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Mast cell-T cell interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

A 30-year perspective on alpha 1-antitrypsin deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Requirement for IL-13 independently of IL-4 in experimental asthma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

cDNA cloning and characterization of the human interleukin 13 receptor alpha chain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Critical protective role of mast cells in a model of acute septic peritonitis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Impaired mast cell-dependent natural immunity in complement C3-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205868200

21 January 2018

Identifiers

10.1074/JBC.M205868200

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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