Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA (Q24302011)

GOA release 2020-03-11

Exonuclease 1

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GOA release 2020-03-11

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1

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Lene Juel Rasmussen

object named as

Lene Juel Rasmussen

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author name string

Anne Charlotte Jäger

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Anne Lützen

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Jens R Bundgaard

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

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language of work or name

English

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publication date

19 February 2004

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published in

Oncogene

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volume

23

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issue

7

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page(s)

1457-68

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cites work

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Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

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Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta

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Mammalian DNA mismatch repair

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

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Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro

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Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase

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Human exonuclease I is required for 5' and 3' mismatch repair

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HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes

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Mechanisms of tolerance to DNA damaging therapeutic drugs

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hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

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The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2

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The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

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The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair

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Recognition of DNA alterations by the mismatch repair system

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The interaction of DNA mismatch repair proteins with human exonuclease I

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The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein

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Inactivation of DNA mismatch repair by increased expression of yeast MLH1.

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Visualization of mismatch repair in bacterial cells

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The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae

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