Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes (Q24302853)

2

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Markus Boehm

3

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Jeremy R Rose

4

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José A Martina

5

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Bong-Yoon Kim

6

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Sundararajan Venkatesan

7

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Juan S Bonifacino

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

8

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language of work or name

English

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publication date

22 December 2003

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published in

Journal of Cell Biology

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volume

163

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page(s)

1281-90

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issue

6

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cites work

1 reference

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ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

19 March 2017

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Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins

19 March 2017

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Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).

19 March 2017

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Structure--function relationships in HIV-1 Nef.

19 March 2017

1 reference

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Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains

19 March 2017

1 reference

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The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

19 March 2017

1 reference

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A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

19 March 2017

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

19 March 2017

1 reference

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

19 March 2017

1 reference

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A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3.

19 March 2017

1 reference

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Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu2

19 March 2017

1 reference

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AP-3: an adaptor-like protein complex with ubiquitous expression

19 March 2017

1 reference

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Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

19 March 2017

1 reference

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Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

19 March 2017

1 reference

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Targeting signals and subunit interactions in coated vesicle adaptor complexes

19 March 2017

1 reference

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Molecular architecture and functional model of the endocytic AP2 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism

19 March 2017

1 reference

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Structural basis for recognition of acidic-cluster dileucine sequence by GGA1

19 March 2017

1 reference

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Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains

19 March 2017

1 reference

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A structural explanation for the recognition of tyrosine-based endocytotic signals

19 March 2017

1 reference

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A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

19 March 2017

1 reference

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HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes

19 March 2017

1 reference

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Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

19 March 2017

1 reference

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Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Sorting of mannose 6-phosphate receptors mediated by the GGAs

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2

19 March 2017

1 reference

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Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

19 March 2017

Clathrin and adaptors

1 reference

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Lysosomal targeting of Limp II membrane glycoprotein requires a novel Leu-Ile motif at a particular position in its cytoplasmic tail

19 March 2017

1 reference

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Interaction of tyrosine-based sorting signals with clathrin-associated proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Signals for sorting of transmembrane proteins to endosomes and lysosomes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Endocytosis and molecular sorting

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

27 September 2017

Adaptor-related proteins

1 reference

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Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells

27 September 2017

1 reference

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The medium subunits of adaptor complexes recognize distinct but overlapping sets of tyrosine-based sorting signals

27 September 2017

1 reference

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Selection of phage displayed peptides from a random 10-mer library recognising a peptide target.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

Refined solution structure and backbone dynamics of HIV-1 Nef.

27 September 2017

1 reference

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Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.

27 September 2017

1 reference

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The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

27 September 2017

1 reference

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Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components

27 September 2017

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

27 September 2017

1 reference

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Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor

27 September 2017

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Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef.

27 September 2017

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Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.

27 September 2017

1 reference

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Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

30 May 2018

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Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail

30 May 2018

1 reference

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A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173715

The accuracy of reverse transcriptase from HIV-1.

30 May 2018

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Mechanism of interaction between leucine-based sorting signals from the invariant chain and clathrin-associated adaptor protein complexes AP1 and AP2.

19 June 2018

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Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain. An acidic cluster containing a key aspartate is important for function in lysosomal enzyme sorting

21 January 2018

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12 December 2020

Hsc70 chaperones clathrin and primes it to interact with vesicle membranes

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12 December 2020

In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI-motif)

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12 December 2020

Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins

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12 December 2020