SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor (Q24303393)

sclerostin

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LDL receptor related protein 6

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negative regulation of canonical Wnt signaling pathway

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Frizzled class receptor 8

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Journal of Biological Chemistry

author name string

Mikhail Semënov

series ordinal

1

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Keiko Tamai

series ordinal

2

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Xi He

series ordinal

3

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language of work or name

English

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publication date

22 July 2005

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published in

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volume

280

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page(s)

26770-5

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issue

29

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cites work

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

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Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

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Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

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Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal

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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

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LRP5 and Wnt signaling: a union made for bone

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High bone density due to a mutation in LDL-receptor-related protein 5

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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An LDL-receptor-related protein mediates Wnt signalling in mice

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Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

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Functional and structural diversity of the human Dickkopf gene family

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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A mechanism for Wnt coreceptor activation

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Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.

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Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

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Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

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Formation and function of Spemann's organizer

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

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The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.

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Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

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Identifiers

DOI

10.1074/JBC.M504308200

1 reference

Consolidated OpenCitations Corpus – April 2017

3463800

3463800

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference