Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association (Q24303798)

positive regulation of NF-kappaB transcription factor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Donghua He

1

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Taoyong Chen

2

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Mingjin Yang

3

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Xuhui Zhu

4

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Chen Wang

5

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Xuetao Cao

6

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Zhen Cai

Journal of Molecular Medicine

7

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language of work or name

English

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publication date

February 2011

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published in

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volume

89

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issue

2

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page(s)

137-50

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exact match

https://scigraph.springernature.com/pub.10.1007/s00109-010-0689-z

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cites work

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Rab proteins as membrane organizers

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Rab27b regulates number and secretion of platelet dense granules

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Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells

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A functional role of Stat3 in in vivo megakaryopoiesis

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Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkap

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Ets-dependent regulation of target gene expression during megakaryopoiesis

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Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro

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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

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Physical and functional interactions between STAT5 and Runx transcription factors

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GATA-1 forms distinct activating and repressive complexes in erythroid cells

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A CD2+ subset of non-malignant peripheral blood lymphocytes from patients with Sézary syndromes overexpress the low-molecular-weight GTP-binding protein Rab2.

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12 December 2020

Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis

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Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endoreplication

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A role for Rab27b in NF-E2-dependent pathways of platelet formation

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12 December 2020

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

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12 December 2020

Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells

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12 December 2020

The alpha(IIb)beta(3) integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34(+) cord blood cells to megakaryocytes

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12 December 2020