Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkap (Q43554036)

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English	Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkap	scientific article

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18 January 2020

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Retraction Watch

29 December 2023

https://doi.org/10.1016/j.jbc.2021.100767

http://retractionwatch.com/?s=%22Xuetao+Cao%22

Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB (English)

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18 January 2020

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hepatocellular carcinoma

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based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

8

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18 January 2020

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Chen Wang

1

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18 January 2020

Taoyong Chen

2

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18 January 2020

Ning Zhang

3

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18 January 2020

Mingjin Yang

4

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18 January 2020

Bai Li

5

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18 January 2020

Xiang Lü

6

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18 January 2020

Xuetao Cao

7

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18 January 2020

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12 December 2008

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18 January 2020

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10

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Journal of Biological Chemistry

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18 January 2020

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18 January 2020

6

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18 January 2020

3804-3813

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18 January 2020

Targeting TRAIL agonistic receptors for cancer therapy.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

[Effects of melittin on expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas ligand in hepatocarcinoma cells]

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Melittin activates endogenous phospholipase D during cytolysis of human monocytic leukemia cells.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Inhibition of the bovine-heart mitochondrial F1-ATPase by cationic dyes and amphipathic peptides

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

TGF-beta activated kinase-1: new insights into the diverse roles of TAK1 in development and immunity

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Apis mellifera venom and melittin block neither NF-kappa B-p50-DNA interactions nor the activation of NF-kappa B, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Signalling pathways of the TNF superfamily: a double-edged sword

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Melittin Cardiotoxicity in Cultured Mouse Cardiac Myocytes and Its Correlation with Calcium Overload

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Melittin: a membrane-active peptide with diverse functions.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1074/JBC.M807191200

Identifiers

10.1074/JBC.M807191200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19074436%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19074436%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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