Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101) (Q24303870)

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1 January 2020

title

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101) (English)

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1 January 2020

main subject

phosphorylation

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Protein kinase C theta

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negative regulation of insulin receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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5

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1 January 2020

Morris J. Birnbaum

8

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1 January 2020

7

Dan R Littman

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1 January 2020

author name string

Yu Li

1

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1 January 2020

Timothy J Soos

2

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1 January 2020

Xinghai Li

3

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1 January 2020

Jiong Wu

4

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1 January 2020

Xiaojian Sun

6

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1 January 2020

Roberto D Polakiewicz

9

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1 January 2020

language of work or name

English

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publication date

10 September 2004

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Journal of Biological Chemistry

1 January 2020

published in

1 reference

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1 January 2020

volume

279

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1 January 2020

page(s)

45304-45307

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1 January 2020

issue

44

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Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity

1 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Protein kinase Ctheta: a new essential superstar on the T-cell stage

1 reference

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7 January 2021

Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

1 reference

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7 January 2021

Insulin signaling pathways in time and space.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

A central role for JNK in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

1 reference

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7 January 2021

Increased protein kinase C theta in skeletal muscle of diabetic patients

1 reference

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7 January 2021

Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells

1 reference

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7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

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7 January 2021

mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control

1 reference

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7 January 2021

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Expression and biochemical characterization of human protein kinase C-theta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

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7 January 2021

Insulin signaling in health and disease

1 reference

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7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Morphine induces desensitization of insulin receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

PKC-theta knockout mice are protected from fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400186200

7 January 2021

Identifiers

DOI

10.1074/JBC.C400186200

2 references

Consolidated OpenCitations Corpus – April 2017

3483872

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15364919%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

3483872

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3483872