Protein kinase C theta (Q21110503)

Protein kinase-like domain superfamily

1 reference

C2 domain superfamily

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

Novel protein kinase C theta, catalytic domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 references

8 April 2019

Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

2 references

protein serine/threonine kinase activity

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

10 September 2018

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

10 September 2018

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

EXP

protein kinase activity

2 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

protein serine/threonine kinase activity

5 references

8 April 2019

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

intracellular anatomical structure

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759

Ensembl genome database project

IBA

immunological synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

microtubule organizing center

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

intracellular signal transduction

IDA

biological process

4 references

8 April 2019

Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

positive regulation of telomere capping

IBA

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

immune system process

1 reference

8 April 2019

positive regulation of telomere maintenance via telomerase

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

Fc-epsilon receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

negative regulation of T cell apoptotic process

negative regulation of insulin receptor signaling pathway

IMP

1 reference

8 April 2019

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

peptidyl-serine phosphorylation

IMP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

regulation of cell growth

IBA

1 reference

8 April 2019

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

positive regulation of T cell proliferation

NAS

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

positive regulation of telomerase activity

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

IMP

inflammatory response

1 reference

8 April 2019

T cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

regulation of megakaryocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL565612

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL494089

has part(s)

AGC-kinase, C-terminal

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

protein kinase, C-terminal

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

serine/threonine-protein kinase, active site

1 reference

diacylglycerol/phorbol-ester binding

1 reference

Novel protein kinase C theta, catalytic domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016