Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification (Q24304218)

regulation of defense response to virus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

He-Xin Shi

1

0 references

Kai Yang

2

0 references

Xing Liu

3

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Xin-Yi Liu

4

0 references

Bo Wei

5

0 references

Yu-Fei Shan

6

0 references

Lian-Hui Zhu

7

0 references

Chen Wang

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

May 2010

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published in

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volume

30

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issue

10

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page(s)

2424-36

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cites work

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Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

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The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

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Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

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A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins

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ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.

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HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets

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Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells

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The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase

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IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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1 reference

12 December 2020

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