RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. (Q27937465)

E3 ubiquitin-protein ligase RAD18 YCR066W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Carsten Hoege

1

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Boris Pfander

2

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George-Lucian Moldovan

3

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George Pyrowolakis

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Stefan Jentsch

Genome maintenance mechanisms for preventing cancer

5

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language of work or name

English

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publication date

12 September 2002

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1 reference

1 December 2016

419

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issue

6903

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page(s)

135-41

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cites work

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MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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SUMO--nonclassical ubiquitin

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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites

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The puzzle of PCNA's many partners

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Molecular cloning, structure and expression of the yeast proliferating cell nuclear antigen gene

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A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

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A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair

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RING finger proteins: mediators of ubiquitin ligase activity

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Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

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The RAD6 gene and protein of Saccharomyces cerevisiae

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Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome

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The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway

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Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis

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PCNA connects DNA replication to epigenetic inheritance in yeast.

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Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon

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An E3-like factor that promotes SUMO conjugation to the yeast septins

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Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

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Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein

21 January 2018

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Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

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Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

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DNA repair genes and proteins of Saccharomyces cerevisiae

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7 January 2021

Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae

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New structural clues to substrate specificity in the "ubiquitin system"

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Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants

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Crystallization of Proliferating Cell Nuclear Antigen (PCNA) from Saccharomyces cerevisiae

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UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae

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7 January 2021