Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation (Q24304387)

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English	Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation	scientific article

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scholarly article

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Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation (English)

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Vitamin K epoxide reductase complex subunit 1

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GOA release 2020-03-11

peptidyl-glutamic acid carboxylation

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GOA release 2020-03-11

(E)-phytonadione

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based on heuristic

inferred from title

Kathleen L Berkner

object named as

Kathleen L Berkner

4

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author name string

Mark A Rishavy

1

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Aisulu Usubalieva

2

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Kevin W Hallgren

3

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language of work or name

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publication date

4 March 2011

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Journal of Biological Chemistry

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286

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9

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7267-78

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Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of a bacterial homologue of vitamin K epoxide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Vitamin K-dependent carboxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

The vitamin K-dependent carboxylase

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

6 April 2017

Vitamin K epoxide reductase: homology, active site and catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Identification of the gene for vitamin K epoxide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

19 March 2017

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

7 April 2017

Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Structure and function of vitamin K epoxide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Purification of vitamin K-dependent carboxylase from cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Selective release of content from microsomal vesicles without membrane disassembly. I. Permeability changes induced by low detergent concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

27 September 2017

Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of histidine 160 disrupts glutamic acid carbanion formation and efficient coupling of vitamin K epoxidation to glutamic acid carboxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

30 May 2018

Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

30 May 2018

Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

VKORC1 mutations in patients with partial resistance to phenprocoumon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.172213

21 January 2018

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

29 November 2018

Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044983

29 November 2018

Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R- and S-Warfarin inhibition of vitamin K and vitamin K 2,3-epoxide reductase activities in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat liver thioredoxin and thioredoxin reductase: purification and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin K-dependent carboxylase. Possible role for thioredoxin in the reduction of vitamin K metabolites in liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with decreased stability of CYP2C9 enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20978134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M110.172213

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