Vitamin K-dependent carboxylation (Q28274354)

https://doi.org/10.1016%2FS0083-6729%2807%2900007-6

27 March 2017

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Kathleen L Berkner

1

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author name string

Kathleen L. Berkner

series ordinal

1

1 reference

https://doi.org/10.1016%2FS0083-6729%2807%2900007-6

27 March 2017

language of work or name

English

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publication date

2008

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https://doi.org/10.1016%2FS0083-6729%2807%2900007-6

27 March 2017

published in

Vitamins and Hormones

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https://doi.org/10.1016%2FS0083-6729%2807%2900007-6

27 March 2017

volume

78

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page(s)

131-56

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131-156

1 reference

https://doi.org/10.1016%2FS0083-6729%2807%2900007-6

gamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates

27 March 2017

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Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation

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Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile

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Vitamin K-dependent oxygenase/carboxylase; differential inactivation by sulfhydryl reagents

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Vitamin K dependent carboxylase: subcellular location of the carboxylase and enzymes involved in Vitamin K metabolism in rat liver

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Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain.

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7 January 2021

A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism

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7 January 2021

Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile

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7 January 2021

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency

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7 January 2021

Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria

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Vitamin K and energy transduction: a base strength amplification mechanism

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Increased bone formation in osteocalcin-deficient mice.

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7 January 2021

Vitamin K-dependent carboxylase: utilization of decarboxylated bone Gla protein and matrix Gla protein as substrates.

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7 January 2021

Protein C activation.

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7 January 2021

Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes

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7 January 2021

Recombinant human activated protein C in the treatment of severe sepsis: an evidence-based review

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7 January 2021

Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16.

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7 January 2021

GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells

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7 January 2021

Some characteristics of a vitamin K-dependent carboxylating system from rat liver microsomes

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7 January 2021

The gamma-carboxylation recognition site is sufficient to direct vitamin K-dependent carboxylation on an adjacent glutamate-rich region of thrombin in a propeptide-thrombin chimera.

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7 January 2021

Vitamin K epoxide reductase: homology, active site and catalytic mechanism

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7 January 2021

Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts

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7 January 2021

Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: implications for the release of vitamin K-dependent proteins

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7 January 2021

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

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7 January 2021

Quality control in the secretory pathway

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7 January 2021

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

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7 January 2021

The role of gamma-carboxylation in the anti-apoptotic function of gas6

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7 January 2021

Recombinant factor VIIa (Novoseven) as a hemostatic agent

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7 January 2021

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range

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7 January 2021

Osteocalcin binds tightly to the gamma-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins.

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7 January 2021

The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes

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7 January 2021

Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins

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7 January 2021

Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues

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7 January 2021

Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade

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7 January 2021

Identification of a Drosophila vitamin K-dependent gamma-glutamyl carboxylase

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7 January 2021

Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons.

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7 January 2021

Identification of the gene for vitamin K epoxide reductase

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7 January 2021

The putative vitamin K-dependent gamma-glutamyl carboxylase internal propeptide appears to be the propeptide binding site

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7 January 2021

Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product

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7 January 2021

Location of gamma-carboxyglutamyl residues in partially carboxylated prothrombin preparations

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7 January 2021

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

1 reference

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7 January 2021

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

1 reference

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7 January 2021

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl

1 reference

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7 January 2021

Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate

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7 January 2021

Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome

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7 January 2021

Expression and characterization of the naturally occurring mutation L394R in human gamma-glutamyl carboxylase.

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7 January 2021

A conserved region of human vitamin K-dependent carboxylase between residues 393 and 404 is important for its interaction with the glutamate substrate

1 reference

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7 January 2021

Prevention of growth arrest-induced cell death of vascular smooth muscle cells by a product of growth arrest-specific gene, gas6

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7 January 2021

Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells

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7 January 2021

Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy.

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7 January 2021

Peptide neurotoxins from fish-hunting cone snails

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7 January 2021

A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase.

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7 January 2021

Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate

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7 January 2021

Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase

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7 January 2021

Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves

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7 January 2021

Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

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7 January 2021

Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity

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7 January 2021

In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells

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7 January 2021

A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine

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7 January 2021

The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation

1 reference

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7 January 2021

Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation

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7 January 2021

The use of recombinant factor VIIa in the treatment of bleeding disorders.

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7 January 2021

Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat

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7 January 2021

Targeted mutagenesis by homologous recombination in D. melanogaster

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7 January 2021

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

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7 January 2021

Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors

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7 January 2021

Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone

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7 January 2021

Two-dimensional crystallization of human vitamin K-dependent gamma-glutamyl carboxylase

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7 January 2021

HTTM, a horizontally transferred transmembrane domain.

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7 January 2021

Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide

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7 January 2021

A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency.

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7 January 2021

Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase

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7 January 2021

Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.

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7 January 2021

Amino acids responsible for reduced affinities of vitamin K-dependent propeptides for the carboxylase

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7 January 2021

The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase

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7 January 2021

Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts

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7 January 2021

Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

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7 January 2021

Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state

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7 January 2021

Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X.

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7 January 2021

Vitamin K-dependent carboxylase

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7 January 2021

The importance of menaquinones in human nutrition

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7 January 2021

Vitamin K-dependent carboxylase: Requirements for carboxylation of soluble peptide substrates and substrate specificity

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7 January 2021

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

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7 January 2021

Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4.

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7 January 2021

Microsomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents

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7 January 2021

Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.

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7 January 2021

Warfarin causes the degradation of protein C precursor in the endoplasmic reticulum

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7 January 2021

Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity

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7 January 2021

Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle

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7 January 2021

On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila

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7 January 2021

Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi

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7 January 2021

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

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7 January 2021

Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase

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7 January 2021

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase

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7 January 2021