Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function (Q24304442)

3

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author name string

Andrea D Basso

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David B Solit

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Banabihari Giri

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Philip Tsichlis

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Neal Rosen

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

18 October 2002

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published in

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volume

277

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issue

42

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page(s)

39858-66

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cites work

Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection*1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The glucose-regulated protein grp94 is related to heat shock protein hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Steroid receptor interactions with heat shock protein and immunophilin chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

7 January 2021

Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

7 January 2021

A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

7 January 2021

Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206322200

7 January 2021

Identifiers

DOI

10.1074/JBC.M206322200

1 reference

Consolidated OpenCitations Corpus – April 2017

2170798

2170798

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference