DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA (Q24305044)

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22 January 2020

title

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA (English)

1 reference

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DNA topoisomerase II alpha

22 January 2020

main subject

1 reference

GOA release 2020-03-11

DNA binding, bending

1 reference

GOA release 2020-03-11

author

Sanghwa Lee

1

1 reference

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22 January 2020

Joseph E Deweese

5

1 reference

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22 January 2020

6

Neil Osheroff

1 reference

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22 January 2020

author name string

Seung-Ryoung Jung

2

1 reference

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22 January 2020

Kang Heo

3

1 reference

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22 January 2020

Jo Ann W Byl

4

1 reference

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22 January 2020

Sungchul Hohng

7

1 reference

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22 January 2020

language of work or name

English

0 references

publication date

9 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 January 2020

published in

1 reference

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22 January 2020

volume

109

1 reference

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22 January 2020

page(s)

2925-2930

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22 January 2020

issue

8

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Targeting DNA topoisomerase II in cancer chemotherapy

22 January 2020

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19 March 2017

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DNA-induced narrowing of the gyrase N-gate coordinates T-segment capture and strand passage

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27 September 2017

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The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

27 September 2017

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DNA sequence selectivity of topoisomerases and topoisomerase poisons.

30 May 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1115704109

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons

21 January 2018

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The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism

21 January 2018

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Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

21 January 2018

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12 December 2020

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

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12 December 2020

DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism

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12 December 2020

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1115704109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

ADS bibcode

2012PNAS..109.2925L

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323612%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

2 references

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