DNA topoisomerase II alpha (Q21108482)

DNA topoisomerase, type IIA-like domain superfamily

1 reference

DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta

1 reference

Ribosomal protein S5 domain 2-type fold

1 reference

DNA topoisomerase, type IIA, subunit B, C-terminal

1 reference

DNA topoisomerase II, eukaryotic-type

1 reference

Ribosomal protein S5 domain 2-type fold, subgroup

1 reference

C-terminal associated domain of TOPRIM, protein family

1 reference

DNA topoisomerase, type IIA, subunit B, domain 2, protein family

1 reference

DNA topoisomerase 2, TOPRIM domain, protein family

1 reference

DNA topoisomerase, type IIA, subunit A/C-terminal domain, protein family

1 reference

DTHCT, protein family

1 reference

Histidine kinase/HSP90-like ATPase family

1 reference

TOPRIM domain, protein family

1 reference

DNA topoisomerase, type IIA, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

13 November 2019

1 reference

13 November 2019

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

ATP-dependent activity, acting on DNA

1 reference

8 April 2019

The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

protein homodimerization activity

1 reference

8 April 2019

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

DNA topoisomerase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

BRCA1 participates in DNA decatenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

10 references

8 April 2019

Metnase promotes restart and repair of stalled and collapsed replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

RNA helicase A interacts with dsDNA and topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

BRCA1 participates in DNA decatenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

protein heterodimerization activity

IPI

1 reference

8 April 2019

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

2 references

protein kinase C binding

1 reference

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

IPI

magnesium ion binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

4 references

8 April 2019

RNA helicase A interacts with dsDNA and topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

HDA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

1 reference

8 April 2019

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

17 October 2017

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

17 October 2017

Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

17 October 2017

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

viral integration complex

1 reference

17 October 2017

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

viral integration complex

1 reference

8 April 2019

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

protein-containing complex

1 reference

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

ribonucleoprotein complex

1 reference

8 April 2019

RNA helicase A interacts with dsDNA and topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

resolution of meiotic recombination intermediates

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

apoptotic chromosome condensation

1 reference

17 October 2017

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

BRCA1 participates in DNA decatenation

chromosome segregation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

DNA metabolic process

1 reference

8 April 2019

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

cellular response to DNA damage stimulus

TAS

1 reference

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

1 reference

8 April 2019

DNA ligation catalyzed by human topoisomerase II alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

chromosome condensation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

hematopoietic progenitor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

positive regulation of apoptotic process

1 reference

8 April 2019

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

mitotic DNA integrity checkpoint signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

positive regulation of viral genome replication

1 reference

17 October 2017

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

1 reference

8 April 2019

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

sister chromatid segregation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

RNA helicase A interacts with dsDNA and topoisomerase IIalpha

DNA topological change

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

8 April 2019

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

negative regulation of DNA duplex unwinding

1 reference

8 April 2019

RNA helicase A interacts with dsDNA and topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

female meiotic nuclear division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7069

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6815

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7242

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1117

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL68117

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL53463

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107818

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL58

doxorubicin hydrochloride

object has role

reaction inhibitor

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL359744

has part(s)

C-terminal associated domain of TOPRIM

1 reference

DNA topoisomerase, type IIA, subunit B, domain 2

1 reference

TOPRIM domain

1 reference

DNA topoisomerase, type IIA, subunit A/C-terminal

1 reference

DNA topoisomerase, type IIA, conserved site

1 reference

DTHCT

1 reference

Histidine kinase/HSP90-like ATPase domain

1 reference

DNA topoisomerase 2, TOPRIM domain

1 reference

Identifiers

MeSH descriptor ID

C000618811

subject named as

TOP2A protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023