Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain (Q24305153)

acetylcholine-gated cation-selective channel activity

GOA release 2020-03-11

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GOA release 2020-03-11

author

Petros Giastas

2

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4 June 2020

Eleftherios Zarkadas

3

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4 June 2020

author name string

Marios Zouridakis

1

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4 June 2020

Dafni Chroni-Tzartou

4

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4 June 2020

Piotr Bregestovski

5

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4 June 2020

Socrates J Tzartos

6

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Nature Structural & Molecular Biology

4 June 2020

language of work or name

English

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publication date

November 2014

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published in

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4 June 2020

volume

21

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4 June 2020

issue

11

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4 June 2020

page(s)

976-980

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The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily

4 June 2020

cites work

1 reference

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

21 January 2018

1 reference

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

21 January 2018

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

21 January 2018

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Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

21 January 2018

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

21 January 2018

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

21 January 2018

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Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

21 January 2018

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Creating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES

21 January 2018

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Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

21 January 2018

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Principles of activation and permeation in an anion-selective Cys-loop receptor

21 January 2018

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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

21 January 2018

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Crystal structure of a human GABAA receptor

21 January 2018

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X-ray structure of the mouse serotonin 5-HT3 receptor

21 January 2018

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Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

21 January 2018

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Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)

21 January 2018

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alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

21 January 2018

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A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit

21 January 2018

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Stoichiometry of the alpha9alpha10 nicotinic cholinergic receptor.

21 January 2018

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Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1.

21 January 2018

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Alpha9 nicotinic acetylcholine receptors and the treatment of pain

21 January 2018

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The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?

21 January 2018

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Expression of soluble ligand- and antibody-binding extracellular domain of human muscle acetylcholine receptor alpha subunit in yeast Pichia pastoris. Role of glycosylation in alpha-bungarotoxin binding

21 January 2018

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Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties

21 January 2018

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Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding

21 January 2018

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Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

21 January 2018

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Recent advances in Cys-loop receptor structure and function

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Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor.

21 January 2018

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In pursuit of the high-resolution structure of nicotinic acetylcholine receptors

21 January 2018

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Principal pathway coupling agonist binding to channel gating in nicotinic receptors

21 January 2018

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Nicotinic receptor transduction zone: invariant arginine couples to multiple electron-rich residues

21 January 2018

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Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.

21 January 2018

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Linking Crystallographic Model and Data Quality

21 January 2018

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Scaling and assessment of data quality

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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Phasercrystallographic software

21 January 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Coot: model-building tools for molecular graphics

21 January 2018

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How good are my data and what is the resolution?

21 January 2018

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Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.

21 January 2018

1 reference

The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A gamma-aminobutyric acid, glycine, and type 3 serotonin receptors.

21 January 2018

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Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

31 March 2020

1 reference

The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2900

2 references

Consolidated OpenCitations Corpus – April 2017

776045

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25282151%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

1031438673

0 references

776045

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

776045

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25282151%20AND%20SRC:MED&resulttype=core&format=json