Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein (Q24306147)

membrane protein proteolysis

GOA release 2020-03-11

1 reference

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

GOA release 2020-03-11

1 reference

Yuri K Moliaka

1

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Anastasia Grigorenko

series ordinal

2

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Dmitri Madera

series ordinal

3

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Evgeny I Rogaev

series ordinal

4

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language of work or name

English

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publication date

16 January 2004

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published in

FEBS Letters

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volume

557

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issue

1-3

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page(s)

185-92

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cites work

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A RIP tide in neuronal signal transduction

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

7 January 2021

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 January 2021

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

7 January 2021

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 January 2021

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

7 January 2021

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

7 January 2021

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

7 January 2021

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Novel class of polytopic proteins with domains associated with putative protease activity

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identification of a novel family of presenilin homologues

1 reference

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

7 January 2021

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

7 January 2021

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

7 January 2021

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

7 January 2021

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The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

7 January 2021

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

7 January 2021

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Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

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7 January 2021

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Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

7 January 2021

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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

7 January 2021

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