Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding (Q24306703)

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English	Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding	scientific article

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13 November 2019

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding (English)

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13 November 2019

phosphorylation

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Forkhead box O1

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GOA release 2020-03-11

positive regulation of transcription by RNA polymerase II

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GOA release 2020-03-11

Andrew D. Mesecar

7

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13 November 2019

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Xiaohui Zhang

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13 November 2019

Lixia Gan

2

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13 November 2019

Haiyun Pan

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13 November 2019

Shaodong Guo

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13 November 2019

Xiaowei He

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13 November 2019

Steven T Olson

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13 November 2019

Stephen Adam

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13 November 2019

Terry G Unterman

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12 September 2002

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13 November 2019

Journal of Biological Chemistry

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13 November 2019

277

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45276-45284

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13 November 2019

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13 November 2019

Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IGFBP-1) promoter and enhances promoter function

1 reference

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7 January 2021

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Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

1 reference

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7 January 2021

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Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

1 reference

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7 January 2021

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ANTHEPROT: an integrated protein sequence analysis software with client/server capabilities.

1 reference

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7 January 2021

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

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7 January 2021

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Transport pathways of macromolecules between the nucleus and the cytoplasm.

1 reference

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7 January 2021

based on heuristic

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell cycle and death control: long live Forkheads

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

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Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

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Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

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7 January 2021

based on heuristic

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Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

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Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

An mRNA splice variant of the AFX gene with altered transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M208063200

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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13 November 2019

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12228231%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

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