An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress (Q24307873)

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5 November 2019

title

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress (English)

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5 November 2019

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GOA release 2020-03-11

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4

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5 November 2019

Yusaku Nakabeppu

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5 November 2019

author name string

Daisuke Yoshimura

1

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5 November 2019

Kunihiko Sakumi

2

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5 November 2019

Mizuki Ohno

3

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5 November 2019

Masato Furuichi

5

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5 November 2019

Shigenori Iwai

6

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5 November 2019

language of work or name

English

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publication date

10 July 2003

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Journal of Biological Chemistry

5 November 2019

published in

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5 November 2019

volume

278

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5 November 2019

issue

39

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5 November 2019

page(s)

37965-37973

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Oxidants, antioxidants, and the degenerative diseases of aging

5 November 2019

cites work

1 reference

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Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation

21 January 2018

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Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli

21 January 2018

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

21 January 2018

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Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

21 January 2018

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Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion

21 January 2018

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cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides

21 January 2018

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Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

21 January 2018

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Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress

21 January 2018

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Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

21 January 2018

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

21 January 2018

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The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

21 January 2018

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Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP

21 January 2018

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Molecular genetics and structural biology of human MutT homolog, MTH1.

21 January 2018

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2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity

21 January 2018

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Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

21 January 2018

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Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

21 January 2018

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Expression of hMTH1 in the hippocampi of control and Alzheimer's disease

21 January 2018

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Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

21 January 2018

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A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

21 January 2018

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Proliferative activation of quiescent Rat-1A cells by delta FosB.

21 January 2018

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Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

21 January 2018

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Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism

21 January 2018

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Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney.

21 January 2018

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Oxidative stress inhibits apoptosis in human lymphoma cells

21 January 2018

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The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

21 January 2018

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

21 January 2018

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Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis

21 January 2018

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Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide

21 January 2018

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

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Four deaths and a funeral: from caspases to alternative mechanisms.

21 January 2018

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Mitochondrial creatine kinase: a major constituent of pathological inclusions seen in mitochondrial myopathies

21 January 2018

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Mitochondrial intermembrane inclusion bodies: the common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics

21 January 2018

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Ultrastructural changes of neuronal mitochondria after transient and permanent cerebral ischemia

21 January 2018

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Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria.

21 January 2018

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21 January 2018

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Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations

21 January 2018

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An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates

21 January 2018

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Chronic progressive external ophthalmoplegia (CPEO): Clinical, morphologic, and biochemical studies

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1074/JBC.M306201200

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12857738%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017