Kinetic mechanism of AKT/PKB enzyme family (Q24307898)

AKT serine/threonine kinase 3

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AKT serine/threonine kinase 2

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ATP binding

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author name string

Xiaoling Zhang

1

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Shiwen Zhang

2

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Harvey Yamane

3

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Robert Wahl

4

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Arisha Ali

5

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Julie A Lofgren

6

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Richard L Kendall

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

19 May 2006

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published in

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volume

281

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issue

20

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page(s)

13949-56

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cites work

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Mechanism of activation and function of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

7 January 2021

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

7 January 2021

Kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

7 January 2021

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

7 January 2021

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601384200

7 January 2021