Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F (Q24309023)

E2F transcription factor 3

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Transcription factor Dp family member 3

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E2F transcription factor 4

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Transcription factor Dp-1

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E2F transcription factor 5

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negative regulation of G1/S transition of mitotic cell cycle

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author

Kristian Helin

10

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author name string

Huan Qiao

1

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Luisa Di Stefano

2

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Chan Tian

3

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Yun-Yan Li

4

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Yan-Hui Yin

5

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Xiao-Ping Qian

6

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Xue-Wen Pang

7

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Yan Li

8

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Michael Allen McNutt

9

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Yu Zhang

11

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Wei-Feng Chen

Journal of Biological Chemistry

12

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language of work or name

English

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publication date

5 January 2007

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published in

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volume

282

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issue

1

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page(s)

454-66

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cites work

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E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas

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E2F-4, a new member of the E2F transcription factor family, interacts with p107

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E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle

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The subcellular localization of E2F-4 is cell-cycle dependent

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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites

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Sibling rivalry in the E2F family

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An E2F-like repressor of transcription

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E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

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E2F-6, a member of the E2F family that can behave as a transcriptional repressor

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E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

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E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains

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E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.

21 January 2018

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Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

21 January 2018

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Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation

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A new component of the transcription factor DRTF1/E2F.

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Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

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In vivo association of E2F and DP family proteins

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Transcription factor E2F binds DNA as a heterodimer

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Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

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The E2F transcriptional network: old acquaintances with new faces

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Pocket proteins and cell cycle control

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Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice

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Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies

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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

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Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells

21 January 2018

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Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1

21 January 2018

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Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP

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Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner

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SWISS-MODEL: An automated protein homology-modeling server

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Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53

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Dp1 is required for extra-embryonic development.

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Dp1 is largely dispensable for embryonic development

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Involvement of E2F transcription factor family in cancer

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E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

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Distinct roles for E2F proteins in cell growth control and apoptosis

21 January 2018

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Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

21 January 2018

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An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry

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A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

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7 January 2021

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

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7 January 2021

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members

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