Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway (Q24309684)

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4 January 2020

title

Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway (English)

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4 January 2020

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2

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4 January 2020

author name string

G Deep

series ordinal

1

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4 January 2020

D J Kroll

series ordinal

3

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4 January 2020

R Agarwal

series ordinal

4

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4 January 2020

language of work or name

English

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publication date

10 March 2008

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4 January 2020

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4 January 2020

volume

27

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4 January 2020

issue

28

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4 January 2020

page(s)

3986-3998

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Myc confers androgen-independent prostate cancer cell growth

4 January 2020

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Molecular determinants of resistance to antiandrogen therapy

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

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Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1.

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Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin

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Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

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Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.

31 March 2020

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Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin

31 March 2020

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Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells

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Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization

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Androgen receptor signaling in androgen-refractory prostate cancer

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Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells.

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Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

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Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

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Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication

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Recent advances in androgen receptor action

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Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats

31 March 2020

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Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

31 March 2020

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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

31 March 2020

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Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: potential therapeutic approaches for prostate cancer.

31 March 2020

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Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells

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HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

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MDM2 promotes ubiquitination and degradation of MDMX

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Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.

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Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone-refractory prostate cancer

31 March 2020

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Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats.

31 March 2020

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Flavonoid antioxidant silymarin and skin cancer

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Prostate cancer chemoprevention by silibinin: bench to bedside

31 March 2020

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Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells

31 March 2020

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Silymarin: a review of its clinical properties in the management of hepatic disorders

31 March 2020

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Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells

31 March 2020

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.45

2 references

Consolidated OpenCitations Corpus – April 2017

1531173

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332867%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 January 2020

1000652383

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1531173

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1531173

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332867%20AND%20SRC:MED&resulttype=core&format=json