Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin (Q40383603)

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scientific article published on February 2006

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English	Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin	scientific article published on February 2006

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scholarly article

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Europe PubMed Central

20 September 2017

Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin (English)

1 reference

Europe PubMed Central

20 September 2017

author name string

Deep G

1

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Europe PubMed Central

20 September 2017

Singh RP

2

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Europe PubMed Central

20 September 2017

Agarwal C

3

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Europe PubMed Central

20 September 2017

Kroll DJ

4

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Europe PubMed Central

20 September 2017

Agarwal R

5

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20 September 2017

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publication date

1 February 2006

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20 September 2017

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Europe PubMed Central

20 September 2017

25

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7

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20 September 2017

1053-1069

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Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209146

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Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

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Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.

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Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells

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Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis.

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis

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Mutations in CHEK2 associated with prostate cancer risk

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The development of androgen-independent prostate cancer

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cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

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Skp2 is oncogenic and overexpressed in human cancers

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The Hallmarks of Cancer

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Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins

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P53, cell cycle control and apoptosis: implications for cancer

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Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

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p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

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Dual-specificity phosphatases as targets for antineoplastic agents

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Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

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Principles of CDK regulation

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Skp2-mediated degradation of p27 regulates progression into mitosis

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Dietary flavonoids and cancer risk: evidence from human population studies

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Cell cycle regulation by the Cdc25 phosphatase family

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Regulation of cyclin-Cdk activity in mammalian cells

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Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents

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Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

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Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm

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CHEK2 variants associate with hereditary prostate cancer

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CDK inhibitors: positive and negative regulators of G1-phase progression

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Prostate cancer prevention by silibinin

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Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance

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Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

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Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons

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Regulation of the G2/M transition by p53.

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Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells

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Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells.

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A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

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Human cell senescence as a DNA damage response.

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Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm

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The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

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The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.

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Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis.

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Requirement of ATM in UVA-induced signaling and apoptosis.

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

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Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition

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10.1038/SJ.ONC.1209146

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Europe PubMed Central

20 September 2017

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Europe PubMed Central

20 September 2017

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