Activation of Src and transformation by an RPTPα splice mutant found in human tumours (Q24310234)

1

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Ling Yao

2

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Rongting Xu

3

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Huacheng Wu

4

0 references

Min Wang

5

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Brian S White

6

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David Shalloway

7

0 references

Xinmin Zheng

Epigenetics in alternative pre-mRNA splicing

8

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language of work or name

English

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publication date

3 August 2011

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published in

The EMBO Journal

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volume

30

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issue

15

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page(s)

3200-11

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cites work

1 reference

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Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation

19 March 2017

1 reference

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The pathobiology of splicing

19 March 2017

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The role of Src in solid tumors

19 March 2017

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Large-scale structural analysis of the classical human protein tyrosine phosphatome

19 March 2017

1 reference

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Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype

19 March 2017

1 reference

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Unusual intron conservation near tissue-regulated exons found by splicing microarrays

19 March 2017

1 reference

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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

19 March 2017

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19 March 2017

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Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation

19 March 2017

1 reference

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Dimerization of receptor protein-tyrosine phosphatase alpha in living cells

19 March 2017

1 reference

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A phosphotyrosine displacement mechanism for activation of Src by PTPalpha

19 March 2017

1 reference

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Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains

19 March 2017

1 reference

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Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation

19 March 2017

1 reference

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Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo

19 March 2017

1 reference

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

19 March 2017

1 reference

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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

19 March 2017

1 reference

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Improved tools for biological sequence comparison

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization

19 March 2017

1 reference

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Galaxy: a web-based genome analysis tool for experimentalists

19 March 2017

1 reference

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Using galaxy to perform large-scale interactive data analyses

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Two mechanisms activate PTPalpha during mitosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane

19 March 2017

1 reference

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Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2

19 March 2017

1 reference

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VISTA: computational tools for comparative genomics

19 March 2017

1 reference

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Aligning multiple genomic sequences with the threaded blockset aligner

7 April 2017

1 reference

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Expansion of the eukaryotic proteome by alternative splicing

7 April 2017

1 reference

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7 April 2017

1 reference

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Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter

7 April 2017

1 reference

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7 April 2017

A renaissance for SRC

1 reference

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Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation

10 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Signal transduction by focal adhesion kinase in cancer

27 September 2017

1 reference

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The spliceosome as target for anticancer treatment

27 September 2017

1 reference

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The multiple lives of NMD factors: balancing roles in gene and genome regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Close sequence comparisons are sufficient to identify human cis-regulatory elements.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Identification and analysis of alternative splicing events conserved in human and mouse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Systematic identification and analysis of exonic splicing silencers.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Structure and regulation of Src family kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Intronic sequences flanking alternatively spliced exons are conserved between human and mouse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Statistical features of human exons and their flanking regions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Empirical statistical estimates for sequence similarity searches.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Association between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. Dual Src homology (SH) 2/SH3 domain requirement and functional consequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

SH2 domain specificity determination using oriented phosphopeptide library

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

The receptor-like protein tyrosine phosphatase HPTP alpha has two active catalytic domains with distinct substrate specificities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Extracellular domain splice variants of a transforming protein tyrosine phosphatase alpha mutant differentially activate Src-kinase dependent focus formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Classification of introns: U2-type or U12-type

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

A tail of two src's: mutatis mutandis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160186

Integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase-alpha is required for cytoskeletal reorganization and cell migration

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

FusionDB: a database for in-depth analysis of prokaryotic gene fusion events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

The emerging role of splicing factors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

Competitive PCR for precise nucleic acid quantification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21725282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21725282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human coagulation factor V is activated to the functional cofactor by elastase and cathepsin G expressed at the monocyte surface

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.212

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2011.212

1 reference

1 reference

1 reference

PubMed publication ID

21725282

1 reference