The role of Src in solid tumors (Q24616659)

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

Europe PubMed Central

title

The role of Src in solid tumors (English)

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author name string

Deric L Wheeler

series ordinal

1

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Mari Iida

series ordinal

2

0 references

Emily F Dunn

series ordinal

3

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language of work or name

English

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publication date

July 2009

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published in

Oncologist

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volume

14

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page(s)

667-78

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issue

7

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cites work

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Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene

7 April 2017

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Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product

7 April 2017

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Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling

7 April 2017

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7 April 2017

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Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells

27 September 2017

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Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines

27 September 2017

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Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

27 September 2017

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Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma

27 September 2017

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A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinoma

27 September 2017

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Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

27 September 2017

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Src, chemoresistance and epithelial to mesenchymal transition: are they related?

27 September 2017

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Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells

27 September 2017

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The Src signaling pathway: a potential target in melanoma and other malignancies

27 September 2017

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CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion.

27 September 2017

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Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma

27 September 2017

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Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

27 September 2017

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Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

27 September 2017

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Treatment for advanced tumors: SRC reclaims center stage

27 September 2017

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Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells

27 September 2017

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Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

27 September 2017

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The SRC-induced mesenchymal state in late-stage colon cancer cells

27 September 2017

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Src protein-tyrosine kinase structure and regulation

27 September 2017

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Src family kinases, key regulators of signal transduction

27 September 2017

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c-Src and cooperating partners in human cancer

27 September 2017

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CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness

27 September 2017

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Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormones

27 September 2017

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Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

27 September 2017

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Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts

27 September 2017

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Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

27 September 2017

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Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

27 September 2017

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Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

27 September 2017

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STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor

27 September 2017

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27 September 2017

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Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis

27 September 2017

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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Nonreceptor Protein Tyrosine Kinases Associated with Neuronal Development

27 September 2017

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27 September 2017

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Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia

27 September 2017

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Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.

30 May 2018

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Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

30 May 2018

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30 May 2018

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Analysis of the c-src gene product structure, abundance, and protein kinase activity in human neuroblastoma and glioblastoma cells

30 May 2018

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Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines.

30 May 2018

1 reference

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

30 May 2018

1 reference

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Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness.

28 November 2018

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siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity

28 November 2018

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Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma.

28 November 2018

1 reference

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Natural history and functional divergence of protein tyrosine kinases

28 November 2018

1 reference

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Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of hu

28 November 2018

1 reference

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Inducible expression of endothelial PAS domain protein-1 by hypoxia in human lung adenocarcinoma A549 cells. Role of Src family kinases-dependent pathway

28 November 2018

1 reference

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Mutation of the SRC gene in endometrial carcinoma.

28 November 2018

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28 November 2018

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Elevated c-yes tyrosine kinase activity in premalignant lesions of the colon

28 November 2018

1 reference

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c-Yes tyrosine kinase activity in human colon carcinoma.

28 November 2018

1 reference

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No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

28 November 2018

1 reference

12 December 2020

Lack of activating c-SRC mutations at codon 531 in rectal cancer

1 reference

12 December 2020

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice

1 reference

12 December 2020

Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice

1 reference

12 December 2020

Alterations in the level of phosphotyrosine signal transduction constituents in human parotid tumors

1 reference

12 December 2020

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

12 December 2020

Overexpression of c-Src in areas of hyperproliferation in head and neck cancer, premalignant lesions and benign mucosal disorders

1 reference

12 December 2020

STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo

1 reference

12 December 2020

Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab

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12 December 2020

10.1634/THEONCOLOGIST.2009-0009

Identifiers

DOI

1 reference

1178275

1178275

1 reference

1 reference

1 reference