A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells (Q24311760)

GOA release 2020-03-11

poly(A) binding

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GOA release 2020-03-11

author name string

Q Tian

1

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M Streuli

2

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H Saito

3

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S F Schlossman

4

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P Anderson

A novel serine proteinase (HuTSP) isolated from a cloned human CD8+ cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes

5

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language of work or name

English

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publication date

1 November 1991

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published in

Cell

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volume

67

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page(s)

629-39

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issue

3

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cites work

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Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes

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Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

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Lambda gt 11: gene isolation with antibody probes and other applications.

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Preparation of extracts from prokaryotes

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A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

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A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression

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A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex.

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A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

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Inhibition of cytolysin activity in large granular lymphocyte granules by lipids: evidence for a membrane insertion mechanism of lysis

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Multiple mechanisms of lymphocyte-mediated killing

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CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

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Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

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Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells

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Structure and function of human perforin

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Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

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Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

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Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail

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The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

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Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization

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Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes

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Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis

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Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

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Purified perforin induces target cell lysis but not DNA fragmentation

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Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

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Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

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Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif

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RNA-binding proteins as developmental regulators

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Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

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Cell death mechanisms and the immune system

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Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

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Perforin-mediated target cell lysis by cytolytic T lymphocytes

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