PAK kinases are directly coupled to the PIX family of nucleotide exchange factors (Q24313368)

GOA release 2020-03-11

signal transduction

1 reference

GOA release 2020-03-11

author name string

E Manser

1

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T H Loo

2

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C G Koh

3

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Z S Zhao

4

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X Q Chen

5

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L Tan

6

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I Tan

7

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T Leung

8

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L Lim

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

9

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language of work or name

English

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publication date

January 1998

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published in

Molecular Cell

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volume

1

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issue

2

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page(s)

183-92

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cites work

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

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The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

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A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures

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IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs

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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

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Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

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A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

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Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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A role for Rac in Tiam1-induced membrane ruffling and invasion

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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

9659915

1 reference

Consolidated OpenCitations Corpus – April 2017