Rho guanine nucleotide exchange factor 7 (Q21101948)

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mammalian protein found in Homo sapiens
  • PAK-interacting exchange factor beta
  • Beta-Pix
  • SH3 domain-containing proline-rich protein
  • Rho guanine nucleotide exchange factor (GEF) 7
  • ARHGEF7
  • rho guanine nucleotide exchange factor 7
  • COOL-1
  • p85
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Language Label Description Also known as
English
Rho guanine nucleotide exchange factor 7
mammalian protein found in Homo sapiens
  • PAK-interacting exchange factor beta
  • Beta-Pix
  • SH3 domain-containing proline-rich protein
  • Rho guanine nucleotide exchange factor (GEF) 7
  • ARHGEF7
  • rho guanine nucleotide exchange factor 7
  • COOL-1
  • p85

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
31 October 2017
stated in
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Mammalian Scribble forms a tight complex with the betaPIX exchange factor
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Nox1 activation by βPix and the role of Ser-340 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
retrieved
31 October 2017
stated in
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IPI
guanyl-nucleotide exchange factor activity
determination method
IEA
EXP
IDA
TAS
7 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
TAS
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q14155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IEA
retrieved
31 October 2017
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
IDA
retrieved
31 October 2017
stated in
Synapse formation is regulated by the signaling adaptor GIT1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
EXP
retrieved
31 October 2017
stated in
Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155
determination method
EXP
cell component
biological process

Identifiers

RefSeq protein ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21101948&oldid=2022917702"