Identification of Nck family genes, chromosomal localization, expression, and signaling specificity (Q24313473)

GOA release 2020-03-11

7

M M Le Beau

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author name string

M Chen

1

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H She

2

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E M Davis

3

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C M Spicer

4

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L Kim

5

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R Ren

6

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W Li

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

25 September 1998

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published in

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volume

273

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issue

39

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page(s)

25171-8

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cites work

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A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance

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The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

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Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development

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The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

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Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

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Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor

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The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

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Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase

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Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

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Binding of NCK to SOS and activation of ras-dependent gene expression

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

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The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

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Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

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A casein kinase I activity is constitutively associated with Nck.

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The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68

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Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac

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A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs

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Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta

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Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome

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Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

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Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

21 January 2018

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

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Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

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Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

21 January 2018

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Hepatocyte growth factor induces activation of Nck and phospholipase C-gamma in lung carcinoma cells

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inferred from DOI database lookup

7 January 2021

based on heuristic

Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses

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