FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination (Q24315150)

Ubiquitin specific peptidase 9 X-linked

1 reference

R-SMAD binding

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Ubiquitin specific peptidase 9, X chromosome

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Graziano Martello

7

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Anant Mamidi

Anant Mamidi

2

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Masafumi Inui

Masafumi Inui

11

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Sirio Dupont

Sirio Dupont

1

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Michelangelo Cordenonsi

Michelangelo Cordenonsi

3

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Stefano Moro

Stefano Moro

12

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author name string

Marco Montagner

4

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Luca Zacchigna

5

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Maddalena Adorno

6

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Michael J Stinchfield

8

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Sandra Soligo

9

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Leonardo Morsut

10

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Nicola Modena

13

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Francesco Argenton

14

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Stuart J Newfeld

15

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Stefano Piccolo

Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification

16

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language of work or name

English

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publication date

9 January 2009

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published in

Cell

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volume

136

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issue

1

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page(s)

123-35

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

A genomic and functional inventory of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

A new twist in Smad signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Structural basis of heteromeric smad protein assembly in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

RING finger proteins: mediators of ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Cloning and expression analysis of a novel mouse gene with sequence similarity to the Drosophila fat facets gene.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Regionally specific induction by the Spemann-Mangold organizer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Dorsal-ventral patterning and neural induction in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021

Ubiquitin-dependent regulation of TGFbeta signaling in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2008.10.051

7 January 2021