Biology of IL-21 and the IL-21 receptor (Q24315354)

Europe PubMed Central

title

Biology of IL-21 and the IL-21 receptor (English)

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main subject

Interleukin 21

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cytokine receptor binding

GOA release 2020-03-11

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

GOA release 2020-03-11

3

Michael J Grusby

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author name string

Devangi S Mehta

series ordinal

1

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Andrea L Wurster

series ordinal

2

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language of work or name

English

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publication date

December 2004

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published in

Immunological Reviews

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volume

202

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page(s)

84-95

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cites work

1 reference

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Interleukin-21 inhibits dendritic cell activation and maturation

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The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma

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Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

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A critical role for IL-21 in regulating immunoglobulin production

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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Cytokines: IL-21 joins the gamma(c)-dependent network?

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Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

20 April 2017

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IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

20 April 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

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The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

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Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses

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IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

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IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

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Interleukin-21 is a growth and survival factor for human myeloma cells

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Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo

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The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo

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The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells

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IL-21 induces the functional maturation of murine NK cells

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Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells

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IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma

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Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma.

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7 January 2021

IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses

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7 January 2021

Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors

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7 January 2021

Cytokines: shared receptors, distinct functions.

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7 January 2021

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction

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7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

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7 January 2021

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

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7 January 2021

Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females

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7 January 2021

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Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo

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7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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7 January 2021

Immune responses in interleukin-2-deficient mice

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7 January 2021

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

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7 January 2021

Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse

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7 January 2021

IL-21 and IL-21 Receptor: A New Cytokine Pathway Modulates Innate and Adaptive Immunity

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7 January 2021

Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability

1 reference

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7 January 2021

IL-21 induces the apoptosis of resting and activated primary B cells

1 reference

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7 January 2021

10.1111/J.0105-2896.2004.00201.X

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

42338

42338

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference