The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2 (Q24316329)

GOA release 2020-03-11

ISL LIM homeobox 1

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positive regulation of transcription regulatory region DNA binding

GOA release 2020-03-11

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GOA release 2020-03-11

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Hui Zhang

1

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Wei-Ping Wang

2

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Ting Guo

3

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Ji-Chun Yang

4

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Ping Chen

5

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Kang-Tao Ma

6

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You-Fei Guan

7

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Chun-Yan Zhou

Journal of Molecular Biology

8

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language of work or name

English

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publication date

25 September 2009

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published in

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volume

392

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issue

3

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page(s)

566-77

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cites work

Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells

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Redox Regulation of in Vitro DNA-binding Activity by the Homeodomain of the Isl-1 Protein

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Regulation of insulin gene transcription

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The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat.

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ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells

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7 January 2021

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

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Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain

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Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

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Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes

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Glucocorticoids suppress β-cell development and induce hepatic metaplasia in embryonic pancreas

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7 January 2021

Glucose regulation of insulin gene expression in pancreatic beta-cells

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7 January 2021

Glucocorticoids and insulin resistance: old hormones, new targets

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Insulin biosynthesis: studies of Islet polyribosomes (nascent peptides-sucrose gradient analysis-gel filtration).

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7 January 2021

The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells

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7 January 2021

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription

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7 January 2021

Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2.

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Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

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Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells

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7 January 2021

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Expression, purification and characterization of the homeodomain of rat ISL-1 protein

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7 January 2021

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

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7 January 2021

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein

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7 January 2021

Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter

1 reference

https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells

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7 January 2021

Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

The LIM/homeodomain protein islet-1 modulates estrogen receptor functions

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Islet Cell and Extrapancreatic Expression of the LIM Domain Homeobox Geneisl-1

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

PDX-1 can repress stimulus-induced activation of the INGAP promoter

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

The insulin gene promoter. A simplified nomenclature.

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021

Heterogeneity in predisposition of hepatic cells to be induced into pancreatic endocrine cells by PDX-1.

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https://api.crossref.org/works/10.1016%2FJ.JMB.2009.07.036

7 January 2021