Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation (Q24316356)

Hisaaki Shinohara

8

0 references

Kamyar Hadian

Kamyar Hadian

5

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Vigo Heissmeyer

Vigo Heissmeyer

10

0 references

Gisela Schimmack

3

Gisela Schimmack

0 references

Michael Düwel

4

Michael Düwel

0 references

Wolfgang Beisker

7

Wolfgang Beisker

0 references

author name string

Andrea C Eitelhuber

1

0 references

Sebastian Warth

2

0 references

Katrin Demski

6

0 references

Tomohiro Kurosaki

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

9

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language of work or name

English

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publication date

2 February 2011

0 references

published in

The EMBO Journal

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volume

30

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issue

3

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page(s)

594-605

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cites work

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Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

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Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation

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CARMA1 is required for Akt-mediated NF-kappaB activation in T cells

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Phosphorylation of the CARMA1 linker controls NF-kappaB activation

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

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CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1

19 March 2017

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Protein phosphatase 2A interacts with and directly dephosphorylates RelA

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CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B

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Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

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Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

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Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells

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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation

19 March 2017

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Alterations of the PPP2R1B gene in human lung and colon cancer

19 March 2017

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Selective modulation of protein kinase C-theta during T-cell activation

19 March 2017

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alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

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Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes

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27 September 2017

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27 September 2017

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CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21157432

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21157432

inferred from PubMed ID database lookup

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based on heuristic

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

1 reference

PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2010.331

1 reference

4143100

4143100

1 reference

1 reference

1 reference