Type 2A protein phosphatase, the complex regulator of numerous signaling pathways (Q24290336)

Protein phosphatase 2 scaffold subunit Aalpha

Europe PubMed Central

title

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways (English)

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main subject

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Protein phosphatase 2 catalytic subunit alpha

GOA release 2020-03-11

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negative regulation of tyrosine phosphorylation of STAT protein

GOA release 2020-03-11

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The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms

GOA release 2020-03-11

author name string

S Zolnierowicz

series ordinal

1

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language of work or name

English

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publication date

15 October 2000

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published in

Biochemical Pharmacology

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volume

60

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issue

8

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page(s)

1225-35

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cites work

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Novel protein serine/threonine phosphatases: variety is the spice of life

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Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999.

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The structure and regulation of protein phosphatases

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Protein serine/threonine phosphatases--new avenues for cell regulation

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Serine/threonine protein phosphatases

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Molecular mechanisms of the protein serine/threonine phosphatases

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Regulation of protein kinase cascades by protein phosphatase 2A.

7 January 2021

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Protein phosphatase 2A: who shall regulate the regulator?

7 January 2021

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Direct metal analyses of Mn2+-dependent and -independent protein phosphatase 2A from human erythrocytes detect zinc and iron only in the Mn2+-independent one

7 January 2021

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B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

7 January 2021

1 reference

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Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

7 January 2021

1 reference

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Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

7 January 2021

1 reference

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The Arabidopsis homolog of yeast TAP42 and mammalian alpha4 binds to the catalytic subunit of protein phosphatase 2A and is induced by chilling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Alpha 4 associates with protein phosphatases 2A, 4, and 6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

On target with a new mechanism for the regulation of protein phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Spatiotemporal distribution of protein kinase and phosphatase activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

An anchoring factor targets protein phosphatase 2A to brain microtubules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Transient translocation and activation of protein phosphatase 2A during mast cell secretion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Inhibitors of protein kinases and phosphatases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Analysis by in vitro mutagenesis of PP2A alpha okadaic acid responsive sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Microcystin affinity purification of plant protein phosphatases: PP1C, PP5 and a regulatory A-subunit of PP2A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Protein phosphatase 2A is required for the initiation of chromosomal DNA replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

AKAPs: from structure to function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Regulation of gene expression by serine/threonine protein phosphatases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Alterations of the PPP2R1B gene in human lung and colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X

Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900424-X