NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation (Q24317458)

cytokine-mediated signaling pathway

GOA release 2020-03-11

1 reference

Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

GOA release 2020-03-11

1 reference

Qi Ma

1

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Li Zhou

series ordinal

2

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Huili Shi

series ordinal

3

0 references

Keke Huo

series ordinal

4

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language of work or name

English

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publication date

June 2008

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published in

Cellular Signalling

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volume

20

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issue

6

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page(s)

1044-51

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cites work

1 reference

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7 January 2021

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

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Negative regulation of cytokine signaling influences inflammation

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

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7 January 2021

Notch signaling in the regulation of tumor angiogenesis

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

Missing pieces in the NF-kappaB puzzle

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Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

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Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis

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7 January 2021

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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Smads keep TABs on inflammation

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Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.

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Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

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7 January 2021

Signalling pathways of the TNF superfamily: a double-edged sword

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

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Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

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Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

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RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

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Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

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Recent insights into the role of Notch signaling in tumorigenesis

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Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells

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TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

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The Notch regulator Numb links the Notch and TCR signaling pathways

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